The patient for pancreas transplantation has usually involvement of multiple organs including eyes, heart and nerves. Therefore, patient should have a detailed cardiac, neurologic and vascular evaluation apart from the regular evaluation for a kidney transplant patient. Patients would undergo Echocardiography, ECG and Stress thallium to evaluate the cardiac condition. Any abnormality in these would require coronary angiography. Doppler or CT scan of abdominal vessels may be required if there is evidence of vascular disease. C-peptide and blood insulin levels are done to confirm absence of insulin. Glycated hemoglobin is measured to know the overall control of blood sugars. Other routine investigations like blood counts, liver function tests, chest X ray are also performed.